已经证明对比学习有效地对未标记数据的预训练图像模型有效，并且有希望的医学图像分类等任务的结果。在预训练期间使用配对文本和图像（例如放射性报告和图像）甚至进一步改善了结果。尽管如此，大多数现有方法将图像分类为下游任务，并且对于像语义分割或物体检测等本地化任务可能不是最佳的。因此，我们提出了从愿景和文本（Lovt）的局部代表学习，以实现我们最佳知识，这是针对本地化医学成像任务的第一种文本监督的预训练方法。我们的方法将实例级图像报告对比学习与图像区域和报告句子表示的局部对比学习结合起来。我们评估LOVT和常用的预培训方法，这些评估框架是由五个公共数据集的胸部X光上的18个本地化任务组成的新评估框架。虽然没有单一的最佳方法，但是，在18个研究的任务中，Lovt在11个中最佳地表现出优选的选择本地化任务的首选方法。

图像生物标准化倡议（IBSI）旨在通过标准化从图像中提取图像生物标志物（特征）的计算过程来提高射致研究的再现性。我们之前建立了169个常用特征的参考值，创建了标准的射频图像处理方案，并开发了用于垄断研究的报告指南。但是，若干方面没有标准化。在这里，我们提出了在射频中使用卷积图像过滤器的参考手册的初步版本。滤波器，例如高斯滤波器的小波或拉普拉斯，在强调特定图像特征（如边缘和Blob）中发挥重要组成部分。已发现从过滤滤波器响应图派生的功能可重复差。此参考手册构成了持续工作的基础，用于标准化卷积滤波器中的覆盖物中的持续工作，并在这项工作进行时更新。

Explainable AI transforms opaque decision strategies of ML models into explanations that are interpretable by the user, for example, identifying the contribution of each input feature to the prediction at hand. Such explanations, however, entangle the potentially multiple factors that enter into the overall complex decision strategy. We propose to disentangle explanations by finding relevant subspaces in activation space that can be mapped to more abstract human-understandable concepts and enable a joint attribution on concepts and input features. To automatically extract the desired representation, we propose new subspace analysis formulations that extend the principle of PCA and subspace analysis to explanations. These novel analyses, which we call principal relevant component analysis (PRCA) and disentangled relevant subspace analysis (DRSA), optimize relevance of projected activations rather than the more traditional variance or kurtosis. This enables a much stronger focus on subspaces that are truly relevant for the prediction and the explanation, in particular, ignoring activations or concepts to which the prediction model is invariant. Our approach is general enough to work alongside common attribution techniques such as Shapley Value, Integrated Gradients, or LRP. Our proposed methods show to be practically useful and compare favorably to the state of the art as demonstrated on benchmarks and three use cases.

Most Graph Neural Networks follow the message-passing paradigm, assuming the observed structure depicts the ground-truth node relationships. However, this fundamental assumption cannot always be satisfied, as real-world graphs are always incomplete, noisy, or redundant. How to reveal the inherent graph structure in a unified way remains under-explored. We proposed PRI-GSL, a Graph Structure Learning framework guided by the Principle of Relevant Information, providing a simple and unified framework for identifying the self-organization and revealing the hidden structure. PRI-GSL learns a structure that contains the most relevant yet least redundant information quantified by von Neumann entropy and Quantum Jensen-Shannon divergence. PRI-GSL incorporates the evolution of quantum continuous walk with graph wavelets to encode node structural roles, showing in which way the nodes interplay and self-organize with the graph structure. Extensive experiments demonstrate the superior effectiveness and robustness of PRI-GSL.

High-utility sequential pattern mining (HUSPM) has emerged as an important topic due to its wide application and considerable popularity. However, due to the combinatorial explosion of the search space when the HUSPM problem encounters a low utility threshold or large-scale data, it may be time-consuming and memory-costly to address the HUSPM problem. Several algorithms have been proposed for addressing this problem, but they still cost a lot in terms of running time and memory usage. In this paper, to further solve this problem efficiently, we design a compact structure called sequence projection (seqPro) and propose an efficient algorithm, namely discovering high-utility sequential patterns with the seqPro structure (HUSP-SP). HUSP-SP utilizes the compact seq-array to store the necessary information in a sequence database. The seqPro structure is designed to efficiently calculate candidate patterns' utilities and upper bound values. Furthermore, a new upper bound on utility, namely tighter reduced sequence utility (TRSU) and two pruning strategies in search space, are utilized to improve the mining performance of HUSP-SP. Experimental results on both synthetic and real-life datasets show that HUSP-SP can significantly outperform the state-of-the-art algorithms in terms of running time, memory usage, search space pruning efficiency, and scalability.

Large language models (LLMs) have demonstrated impressive capabilities in natural language understanding and generation, but the quality bar for medical and clinical applications is high. Today, attempts to assess models' clinical knowledge typically rely on automated evaluations on limited benchmarks. There is no standard to evaluate model predictions and reasoning across a breadth of tasks. To address this, we present MultiMedQA, a benchmark combining six existing open question answering datasets spanning professional medical exams, research, and consumer queries; and HealthSearchQA, a new free-response dataset of medical questions searched online. We propose a framework for human evaluation of model answers along multiple axes including factuality, precision, possible harm, and bias. In addition, we evaluate PaLM (a 540-billion parameter LLM) and its instruction-tuned variant, Flan-PaLM, on MultiMedQA. Using a combination of prompting strategies, Flan-PaLM achieves state-of-the-art accuracy on every MultiMedQA multiple-choice dataset (MedQA, MedMCQA, PubMedQA, MMLU clinical topics), including 67.6% accuracy on MedQA (US Medical License Exam questions), surpassing prior state-of-the-art by over 17%. However, human evaluation reveals key gaps in Flan-PaLM responses. To resolve this we introduce instruction prompt tuning, a parameter-efficient approach for aligning LLMs to new domains using a few exemplars. The resulting model, Med-PaLM, performs encouragingly, but remains inferior to clinicians. We show that comprehension, recall of knowledge, and medical reasoning improve with model scale and instruction prompt tuning, suggesting the potential utility of LLMs in medicine. Our human evaluations reveal important limitations of today's models, reinforcing the importance of both evaluation frameworks and method development in creating safe, helpful LLM models for clinical applications.

Kernel machines have sustained continuous progress in the field of quantum chemistry. In particular, they have proven to be successful in the low-data regime of force field reconstruction. This is because many physical invariances and symmetries can be incorporated into the kernel function to compensate for much larger datasets. So far, the scalability of this approach has however been hindered by its cubical runtime in the number of training points. While it is known, that iterative Krylov subspace solvers can overcome these burdens, they crucially rely on effective preconditioners, which are elusive in practice. Practical preconditioners need to be computationally efficient and numerically robust at the same time. Here, we consider the broad class of Nystr\"om-type methods to construct preconditioners based on successively more sophisticated low-rank approximations of the original kernel matrix, each of which provides a different set of computational trade-offs. All considered methods estimate the relevant subspace spanned by the kernel matrix columns using different strategies to identify a representative set of inducing points. Our comprehensive study covers the full spectrum of approaches, starting from naive random sampling to leverage score estimates and incomplete Cholesky factorizations, up to exact SVD decompositions.

The xView2 competition and xBD dataset spurred significant advancements in overhead building damage detection, but the competition's pixel level scoring can lead to reduced solution performance in areas with tight clusters of buildings or uninformative context. We seek to advance automatic building damage assessment for disaster relief by proposing an auxiliary challenge to the original xView2 competition. This new challenge involves a new dataset and metrics indicating solution performance when damage is more local and limited than in xBD. Our challenge measures a network's ability to identify individual buildings and their damage level without excessive reliance on the buildings' surroundings. Methods that succeed on this challenge will provide more fine-grained, precise damage information than original xView2 solutions. The best-performing xView2 networks' performances dropped noticeably in our new limited/local damage detection task. The common causes of failure observed are that (1) building objects and their classifications are not separated well, and (2) when they are, the classification is strongly biased by surrounding buildings and other damage context. Thus, we release our augmented version of the dataset with additional object-level scoring metrics https://gitlab.kitware.com/dennis.melamed/xfbd to test independence and separability of building objects, alongside the pixel-level performance metrics of the original competition. We also experiment with new baseline models which improve independence and separability of building damage predictions. Our results indicate that building damage detection is not a fully-solved problem, and we invite others to use and build on our dataset augmentations and metrics.

Neuromorphic systems require user-friendly software to support the design and optimization of experiments. In this work, we address this need by presenting our development of a machine learning-based modeling framework for the BrainScaleS-2 neuromorphic system. This work represents an improvement over previous efforts, which either focused on the matrix-multiplication mode of BrainScaleS-2 or lacked full automation. Our framework, called hxtorch.snn, enables the hardware-in-the-loop training of spiking neural networks within PyTorch, including support for auto differentiation in a fully-automated hardware experiment workflow. In addition, hxtorch.snn facilitates seamless transitions between emulating on hardware and simulating in software. We demonstrate the capabilities of hxtorch.snn on a classification task using the Yin-Yang dataset employing a gradient-based approach with surrogate gradients and densely sampled membrane observations from the BrainScaleS-2 hardware system.

Neural image classifiers are known to undergo severe performance degradation when exposed to input that exhibits covariate-shift with respect to the training distribution. Successful hand-crafted augmentation pipelines aim at either approximating the expected test domain conditions or to perturb the features that are specific to the training environment. The development of effective pipelines is typically cumbersome, and produce transformations whose impact on the classifier performance are hard to understand and control. In this paper, we show that recent Text-to-Image (T2I) generators' ability to simulate image interventions via natural-language prompts can be leveraged to train more robust models, offering a more interpretable and controllable alternative to traditional augmentation methods. We find that a variety of prompting mechanisms are effective for producing synthetic training data sufficient to achieve state-of-the-art performance in widely-adopted domain-generalization benchmarks and reduce classifiers' dependency on spurious features. Our work suggests that further progress in T2I generation and a tighter integration with other research fields may represent a significant step towards the development of more robust machine learning systems.